A switch in enantiomer preference between mitochondrial F 1F 0-ATPase chemotypes
The preferred absolute configuration of two series of F 1F 0-ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same ‘triaryl’ pharmacophore to the enzyme binding site. The preferred absolute configuration...
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Published in | Bioorganic & medicinal chemistry letters Vol. 15; no. 11; pp. 2749 - 2751 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
2005
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Subjects | |
Online Access | Get full text |
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Summary: | The preferred absolute configuration of two series of F
1F
0-ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same ‘triaryl’ pharmacophore to the enzyme binding site.
The preferred absolute configuration of two series of F
1F
0-ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same ‘triaryl’ pharmacophore to the enzyme binding site. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2005.03.115 |