Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 4

A series of 1-(1 H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connect...

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Published inBioorganic & medicinal chemistry letters Vol. 14; no. 10; pp. 2653 - 2656
Main Authors Rocco, Vincent P., Spinazze, Patrick G., Kohn, Todd J., Honigschmidt, Nicholas A., Nelson, David L., Bradley Wainscott, D., Ahmad, Laura J., Shaw, Janice, Threlkeld, Penny G., Wong, David T., Takeuchi, Kumiko
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2004
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Summary:A series of 1-(1 H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring. A series of 1-(1 H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.02.088