Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT 1A receptor antagonism/SSRI activities. Part 3
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT 1A receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1 H-indol-4-yloxy)-3-(4-benzo[ b]thiophen-2-ylpiperidinyl)propan-2-ols further improved the in vitro bi...
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Published in | Bioorganic & medicinal chemistry letters Vol. 13; no. 22; pp. 3939 - 3942 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
2003
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Online Access | Get full text |
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Summary: | A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT
1A receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1
H-indol-4-yloxy)-3-(4-benzo[
b]thiophen-2-ylpiperidinyl)propan-2-ols further improved the in vitro binding affinities and functional antagonism.
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT
1A receptor antagonism and serotonin reuptake inhibition was discovered. Modification of potential metabolic sites of 1-(1
H-indol-4-yloxy)-3-(4-benzo[
b]thiophen-2-ylpiperidinyl)propan-2-ols further improved the in vitro binding affinities and functional antagonism. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2003.09.002 |