Achiral, selective CCK 2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template

Novel, achiral 1 H-1,3,5-benzotriazepine-2,4(3 H,5 H)-diones have been prepared and structurally characterized. These compounds are potent CCK 2 receptor antagonists that display a high degree of selectivity over CCK 1 receptors. Novel, achiral 1 H-1,3,5-benzotriazepine-2,4(3 H,5 H)-diones have been...

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Bibliographic Details
Published inBioorganic & medicinal chemistry Vol. 16; no. 6; pp. 2974 - 2983
Main Authors Spencer, John, Gaffen, John, Griffin, Eric, Harper, Elaine A., Linney, Ian D., McDonald, Iain M., Roberts, Sonia P., Shaxted, Mark E., Adatia, Trushar, Bashall, Alan
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2008
Subjects
Antagonist
Benzotriazepine
CCK
CCK 2
Gastrin
CCK 2
Gastrin
CCK
Antagonist
Benzotriazepine
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Summary:Novel, achiral 1 H-1,3,5-benzotriazepine-2,4(3 H,5 H)-diones have been prepared and structurally characterized. These compounds are potent CCK 2 receptor antagonists that display a high degree of selectivity over CCK 1 receptors. Novel, achiral 1 H-1,3,5-benzotriazepine-2,4(3 H,5 H)-diones have been prepared and structurally characterized. These compounds are potent CCK 2 receptor antagonists that display a high degree of selectivity over CCK 1 receptors.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2007.12.047