Phospholipase A 2 expression in tumours: a target for therapeutic intervention?

Phospholipase A 2 (PLA 2) enzymes are involved in lipid metabolism and, as such, are central to several cellular processes. The different PLA 2s identified to date can be classified into three groups: secreted PLA 2 (sPLA 2), calcium-independent PLA 2 (iPLA 2) and calcium-dependent cytosolic PLA 2 (...

Full description

Saved in:
Bibliographic Details
Published inDrug Discovery Today Vol. 8; no. 15; pp. 710 - 716
Main Authors Laye, Jonathan P, Gill, Jason H
Format Book Review
LanguageEnglish
Published Elsevier Ltd 2003
Subjects
arachidonic acid
cPLA 2
molecular target
Phospholipase A 2
sPLA 2
arachidonic acid
Phospholipase A 2
Cancer biology
Pharmaceutical Science
sPLA 2
Drug Discovery
cPLA 2
molecular target
Online AccessGet full text

Cover

More Information
Summary:Phospholipase A 2 (PLA 2) enzymes are involved in lipid metabolism and, as such, are central to several cellular processes. The different PLA 2s identified to date can be classified into three groups: secreted PLA 2 (sPLA 2), calcium-independent PLA 2 (iPLA 2) and calcium-dependent cytosolic PLA 2 (cPLA 2). In addition to their role in cellular signalling, PLA 2s have been implicated in diverse pathological conditions, including inflammation, tissue repair and cancer. Elevated levels of sPLA 2 and cPLA 2 have been reported in several tumour types. Here, we summarize the current views on the PLA 2s, and look at their expression, role in human malignancy and potential as targets for anticancer drug development. In addition to cell signalling, a role for the phospholipase A 2 enzymes has been reported in human malignancy. As such, these enzymes (sPLA 2, cPLA 2, iPLA 2) are potential targets for anticancer drug development.
ISSN:1359-6446
1878-5832
DOI:10.1016/S1359-6446(03)02754-5