Preparation of 99mTc-C 60(OH) x and its biodistribution studies

The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C 60 derivative for biodistriburtion studies, the 99mTc-labeling of C 60(OH) x was optimized. Gamma counting and single photon emission computed tomography (SPECT) were...

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Published inNuclear medicine and biology Vol. 29; no. 6; pp. 707 - 710
Main Authors Qingnuan, Li, yan, Xiu, Xiaodong, Zhang, Ruili, Liu, qieqie, Du, Xiaoguang, Shun, Shaoliang, Chen, Wenxin, Li
Format Journal Article
LanguageEnglish
Published Elsevier Inc 2002
Subjects
99mTc-labeled
activity test
biodistribution
C 60(OH) x
SPECT imaging
biodistribution
activity test
99mTc-labeled
C 60(OH) x
SPECT imaging
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Summary:The biological behavior of fullerene derivatives shows their considerable potential for medical applications. In order to provide a C 60 derivative for biodistriburtion studies, the 99mTc-labeling of C 60(OH) x was optimized. Gamma counting and single photon emission computed tomography (SPECT) were used to assess the biodistribution of the 99mTc-labeled compound in mice and rabbits. Biodistribution studies in mice and imaging of rabbits indicated that 99mTc-C 60(OH) x was widely distributed in all tissues. A significant percentage of total activity was retained for 48 h, particularly in the kidneys, bone, spleen, and liver. All tissues displayed a slow clearance over 48 h, except for bone, which showed slightly increasing localization within 24 h.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(02)00313-X