2,4-Disubstituted oxazoles and thiazoles as latent pharmacophores for diacylhydrazine of SC-51089, a potent PGE 2 antagonist

8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride ( 1, SC-51089) is a functional PGE 2 antagonist selective for the EP 1 receptor subtype with antinociceptive activity. 1,2 Analogues of SC-51089, in which the diacylhydrazine moiety...

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Published inBioorganic & medicinal chemistry Vol. 9; no. 1; pp. 1 - 6
Main Authors Hallinan, E.Ann, Hagen, Timothy J., Tsymbalov, Sofya, Stapelfeld, Awilda, Savage, Michael A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2001
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Summary:8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride ( 1, SC-51089) is a functional PGE 2 antagonist selective for the EP 1 receptor subtype with antinociceptive activity. 1,2 Analogues of SC-51089, in which the diacylhydrazine moiety has been replaced with 2,4-disubstituted-oxazoles and-thiazoles, are described.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)00229-7