Monoacetyldiglycerides as new Ca 2+ mobilizing agents in rat pancreatic acinar cells

• Published in: Bioorganic & medicinal chemistry letters Vol. 9; no. 1; pp. 59 - 64
• Main Authors: Han, So-Yeop, Cho, So-Hye, Kim, So-Yeon, Seo, Jeong-Taeg, Moon, Seok-Jun, Jhon, Gil-Ja
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 1999
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(98)00690-8

Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca 2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca 2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity. Seven monoacetyldiglycerides were synthesized from glycerol in search for new Ca 2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca 2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.