[formula omitted]-alkoxyphenol leukotriene B 4 receptor antagonists

A series of ortho -alkoxyphenols containing a tetrazole acid sidechain have been prepared as antagonists of leukotriene B 4 receptors. These compounds were tested as receptor antagonists of human neutrophil and guinea pig lung membrane leukotriene B 4 receptors. Compounds in this series were found t...

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Published inBioorganic & medicinal chemistry letters Vol. 2; no. 12; pp. 1669 - 1674
Main Authors Sofia, Michael J., Jackson, William T., Saussy, Davis L., Silbaugh, Steven A., Froelich, Larry L., Cockerham, Sandra L., Stengel, Peter W.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1992
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Summary:A series of ortho -alkoxyphenols containing a tetrazole acid sidechain have been prepared as antagonists of leukotriene B 4 receptors. These compounds were tested as receptor antagonists of human neutrophil and guinea pig lung membrane leukotriene B 4 receptors. Compounds in this series were found to be up to 18-fold more potent than LY255283. These results indicate that the acyl group of the 1,2,4,5 substituted hydroxyacetophenone class of LTB 4 antagonists is not critical to antagonist potency. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80453-9