Biologically active oligodeoxyribonucleotides. Part 12: 1N2-Methylation of 2′-deoxyguanosines enhances stability of parallel G-quadruplex and anti-HIV-1 activity

2′-Deoxyguanosine residues of a 3′,5′-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N 2-methyl-2′-deoxyguanosine (m 2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs i...

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Published inBioorganic & medicinal chemistry letters Vol. 10; no. 19; pp. 2213 - 2216
Main Authors Koizumi, Makoto, Akahori, Keika, Ohmine, Toshinori, Tsutsumi, Shinya, Sone, Junko, Kosaka, Toshiyuki, Kaneko, Masakatsu, Kimura, Satoshi, Shimada, Kaoru
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2000
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Summary:2′-Deoxyguanosine residues of a 3′,5′-end-modified hexadeoxyribonucleotide (R-95288) with anti-HIV-1 activity were substituted with N 2-methyl-2′-deoxyguanosine (m 2dG). These modified oligodeoxyribonucleotides (ODNs) showed a 2-fold higher activity than R-95288. Also, the CD spectra of these ODNs indicated that the m 2dG modification stabilized the tertiary structure of the G-quadruplex.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00432-7