Cyclodextrins, cyclomannins, and cyclogalactins with five and six (1→4)-linked sugar units: A comparative assessment of their conformations and hydrophobicity potential profiles 1

A molecular modeling study of the (1→4)-linked cyclooligosaccharides containing five and six α- D-glucose, α- D-mannose, and β- D-galactose units, respectively, provide a clear conception of their overall conformations, their contact surfaces, and their cavity proportions. A MOLCAD-based generation...

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 5; no. 11; pp. 2045 - 2060
Main Authors Lichtenthaler, Frieder W., Immel, Stefan
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1994
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Summary:A molecular modeling study of the (1→4)-linked cyclooligosaccharides containing five and six α- D-glucose, α- D-mannose, and β- D-galactose units, respectively, provide a clear conception of their overall conformations, their contact surfaces, and their cavity proportions. A MOLCAD-based generation of their molecular lipophilicity potential (MLP's) gives a lucid picture of their hydrophobic and hydrophilic surface areas, and hence, a first estimation of their inclusion properties. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(00)86283-7