192P - Mesothelin and Individual Characteristics in a Cohort of Asbestos Exposed Workers

• Published in: Annals of oncology Vol. 23; p. ix80
• Main Authors: Mencoboni, M., Michelazzi, L.A., Cioè, A., Bruzzone, A., Delcorso, L., Mortara, V., Marroni, P., Dini, G., Marcenaro, S., Spigno, F.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2012
• ISSN: 0923-7534; 1569-8041
• DOI: 10.1016/S0923-7534(20)32756-3

The soluble mesothelin-related peptide (SMRP) is a candidate marker in the diagnosis and prognosis of mesothelioma, as well as in the screening of subjects with asbestos exposure. SMRP seems to be influenced by some individual characteristics and clinical factors. The objective of this study was to evaluate the association between serum SMRP and some individual characteristics in 1704 subjects exposed to asbestos for working reasons. Participants underwent clinical examination and were interviewed on medical history, occupational exposure, smoking and weight. SMRP was measured by a ELISA assay. Median SMRP was 0.45 (IQR 0.30-0.67) nmol/l. SMRP was correlated with age (p < 0.001) and was higher in current smokers than in former-smokers or never-smokers (p < 0.001). An inverse association was found between the marker and BMI (p < 0.001). Overall, SMRP concentration was lower in healthy subjects (N 1217, median 0.43 nmol/l) than in all benign diseases (N 357, median 0.51 nmol/l; p < 0.001) and in tumors (N 118, median 0.52 nmo/l, p = 0.03). Serum SMRP values were higher in non neoplastic subjects in which an asbestos-related pleural lesion (APL) was diagnosed (N 152, median 0.65 nmol/l) with respect tumors (p = 0.003). Median SMRP was 0.61 nmol/l in APL alone and 1.13 nmol/l when the lesions were associated with other benign diseases. Multivariate analysis confirmed the positive association between SMRP and age, smoking and asbestos-related pleural lesions, while SMRP was confirmed to be inversely associated with body mass index. Data on a large series of subjects with asbestos exposure confirmed that serum SMRP is associated to a number of clinical and demographic variables. All authors have declared no conflicts of interest.