Preparation of a novel 16-DPA-P 2S 5 adduct and its application as a masked α,β-unsaturated ketone in [4+2]cycloaddition reactions
The reaction of 16-DPA with P 4S 10 in refluxing benzene afforded a novel adduct 16-DPA-P 2S 5 instead of the expected thione. The adduct undergoes [4+2]cycloaddition with alkyne dienophiles to afford steroidal (17,16- c)pyrans. Graphic
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Published in | Tetrahedron letters Vol. 44; no. 13; pp. 2741 - 2744 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
2003
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Subjects | |
Online Access | Get full text |
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Summary: | The reaction of 16-DPA with P
4S
10 in refluxing benzene afforded a novel adduct 16-DPA-P
2S
5 instead of the expected thione. The adduct undergoes [4+2]cycloaddition with alkyne dienophiles to afford steroidal (17,16-
c)pyrans.
Graphic |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/S0040-4039(03)00324-1 |