Synthesis of new N, N-disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones

• Published in: Farmaco (Società chimica italiana : 1989) Vol. 56; no. 8; pp. 625 - 628
• Main Authors: Longobardi, Mario, Mariani, Emilia, Bargagna, Alberto, Mazzeo, Filomena, Vitelli, Maria Redenta, Giordano, Lucio, Falcone, Giuseppe
• Format: Journal Article
• Language: English
• Published: Elsevier SAS 2001
• Subjects: Anaesthetic activity; N, N-Disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones; N, N-Disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones; Anaesthetic activity
• ISSN: 0014-827X; 1879-0569
• DOI: 10.1016/S0014-827X(01)01116-8

The synthesis of some N,N-disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones ( 4a– f), by reaction of phenylchloroketene with a series of N,N-disubstituted ( E)-5-aminomethylene-6,7-dihydrobenzo[b]thiophen-4(5)-ones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. A moderate local anaesthetic activity was observed in the title compounds, particularly in 4e.