Synthesis of new N, N-disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones
The synthesis of some N,N-disubstituted 4-amino-5,6-dihydro-3-phenyl-2 H-thieno[2,3- h]-1-benzopyran-2-ones ( 4a– f), by reaction of phenylchloroketene with a series of N,N-disubstituted ( E)-5-aminomethylene-6,7-dihydrobenzo[b]thiophen-4(5)-ones, followed by dehydrochlorination in situ of the prima...
Saved in:
Published in | Farmaco (Società chimica italiana : 1989) Vol. 56; no. 8; pp. 625 - 628 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier SAS
2001
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The synthesis of some
N,N-disubstituted 4-amino-5,6-dihydro-3-phenyl-2
H-thieno[2,3-
h]-1-benzopyran-2-ones (
4a–
f), by reaction of phenylchloroketene with a series of
N,N-disubstituted (
E)-5-aminomethylene-6,7-dihydrobenzo[b]thiophen-4(5)-ones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. A moderate local anaesthetic activity was observed in the title compounds, particularly in
4e. |
---|---|
ISSN: | 0014-827X 1879-0569 |
DOI: | 10.1016/S0014-827X(01)01116-8 |