15 - Nanodiamond: Designing the Bio-Platform

• Published in: Ultrananocrystalline Diamond pp. 529 - 557
• Main Authors: Grichko, Varvara P., Shenderova, Olga A.
• Format: Book Chapter
• Language: English
• Published: William Andrew Publishing 2006
• ISBN: 9780815515241; 0815515243
• DOI: 10.1016/B978-081551524-1.50017-2

This chapter discusses various methods of surface modification for the development of functionalized diamond nanoparticles for biomedical applications. To be used in biomedical applications, nanoparticles must be biocompatible, non-toxic, non-detective by immune systems, and should not induce side effects. Size control of particles is a prerequisite for biomedical applications. Carbon nanostructures span the same length scale as bio-compounds, ranging from subnanometer-size nucleotides to tens and hundreds of nanometer-sized organelles and viruses, and up to micron-sized cell sizes. The chapter also summarizes different approaches to the surface functionalization of nanodiamonds (ND) particles—that is, the key in successful biomedical applications followed by a discussion of modification of diamond surfaces with nucleic acids and proteins. Both current and potential applications of diamond films and particles in the area of biosensing are addressed.