Tumor uptake of [ 48V]Vanadyl-chlorine e 6Na as a tumor-imaging agent in tumor-bearing mice

[ 48V]Vanadyl-chlorine e 6Na ( 48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e 6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were...

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Published inInternational journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Vol. 17; no. 8; pp. 775,779 - 777,780
Main Authors Iwai, Kuni, Kimura, Shuichi, Ido, Tatsuo, Iwata, Ren
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 1990
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Summary:[ 48V]Vanadyl-chlorine e 6Na ( 48V-Chl) which was synthesized by insertion of 48V (positron emitter) into chlorine e 6Na (Chl), a chlorophyll derivative having a similar structure to pheophorbide-a (Pheo), localized rapidly in experimental mammary carcinoma. The tumor-to-organ ratios of 48V-Chl were higher than those of 48V-labeled Pheo ( 48V-Pheo), and 48V-Chl showed a clear tumor image with low accumulation in liver, depending on the biodistribution of metal-free Chl having an affinity with tumor. 48V-Chl seems to be more suitable than 48V-Pheo as a tumor-imaging agent for photodynamic therapy of tumors.
ISSN:0883-2897
DOI:10.1016/0883-2897(90)90025-V