Histologic studies of human skin test responses to ragweed and compound [formula omitted]: II. Effects of corticosteroid therapy

In a controlled study, a 1-week course of a moderate dosage of corticosteroids given to ragweed-sensitive subjects was associated with a statistically significant decrease in blood eosinophil levels and tissue eosinophil, but not mast cell, responses to ragweed antigen and compound 48 80 , This ther...

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 55; no. 4; pp. 232 - 240
Main Authors Slott, Robert I., Zweiman, Burton
Format Journal Article
LanguageEnglish
Published Mosby, Inc 1975
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ISSN0091-6749
DOI10.1016/0091-6749(75)90142-6

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Summary:In a controlled study, a 1-week course of a moderate dosage of corticosteroids given to ragweed-sensitive subjects was associated with a statistically significant decrease in blood eosinophil levels and tissue eosinophil, but not mast cell, responses to ragweed antigen and compound 48 80 , This therapy did not affect IgE-class anti-ragweed antibody levels or gross whealing responses to antigen or compound 48 80 . While these findings suggest indirectly that a major component of the corticosteroid effect is likely an alteration of the mobilisation of eosinophils to the inflammatory site, additional studies will be required to more directly characterize the mechanisms involved.
ISSN:0091-6749
DOI:10.1016/0091-6749(75)90142-6