Pharmacotherapeutics of prostaglandin E 2 and 15 (S) 15-methyl prostaglandin F 2α in chronic schistosomal bladder ulcer: A clinico-endoscopic study

The pharmacotherapeutic effects of prostaglandin E 2 (PGE 2) and 15 (S) 15-methyl PGF 2α given by different routes of administration, were studied in 20 normal persons and 100 patients with chronic schistosomal bladder ulcer in comparison to normal saline and antimony dimercaptosuccinate drug. Prost...

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Published inProstaglandins Vol. 24; no. 1; pp. 97 - 104
Main Authors El-Gendi, M.A., Nassar, S.H., Toppozada, M., Abdel-Raheem, F.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1982
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Summary:The pharmacotherapeutic effects of prostaglandin E 2 (PGE 2) and 15 (S) 15-methyl PGF 2α given by different routes of administration, were studied in 20 normal persons and 100 patients with chronic schistosomal bladder ulcer in comparison to normal saline and antimony dimercaptosuccinate drug. Prostaglandins produced a rapid significant amelioration in the ulcer symptom complex with a good percentage of ulcer disappearance on cystoscopy, while the antimony dimercaptosuccinate treated group showed a less early response which improved with follow up. This was in contrast to prostaglandins which showed relapse in the symptom-complex in some cases after a follow up period of 2 months. The combined use of schistosomicidal drugs together with, or followed by, prostaglandins might give better results.
ISSN:0090-6980
DOI:10.1016/0090-6980(82)90181-2