On the role of α 1-acid glycoprotein in determining the species specificity of blood-volume expanders from bovine serum
An investigation was made to elucidate the cause of serological species specificity of diverse blood-volume expanders derived from modified bovine serum. Special attention was given to the isolation and identification of a thermostable structure in bovine serum supposed to bear this specific activit...
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| Published in | Clinica chimica acta Vol. 9; no. 5; pp. 491 - 496 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
1964
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| Online Access | Get full text |
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| Summary: | An investigation was made to elucidate the cause of serological species specificity of diverse blood-volume expanders derived from modified bovine serum. Special attention was given to the isolation and identification of a thermostable structure in bovine serum supposed to bear this specific activity. Results of serological reactions between rabbit anti-bovine serum and various native and heat-denatured fractions of bovine serum revealed the seromucoid nature of the active component. Further study of chemical and physico-chemical properties led to the conclusion that the thermostable species-specific component under study was the α
1-acid glycoprotein. |
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| ISSN: | 0009-8981 1873-3492 |
| DOI: | 10.1016/0009-8981(64)90087-7 |