Anti-mutagenic chalcones: Antagonizing the mutagenicity of benzo(a)pyrene on [formula omitted]

Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 – 700 times stronger than that of L-ascorbic acid. Ef...

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Published inBiochemical and biophysical research communications Vol. 112; no. 3; pp. 833 - 842
Main Authors Torigge, Toshie, Arisawa, Mikio, Itoh, Sayuri, Fujiu, Morio, Maruyama, Hiromi B.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1983
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Summary:Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 – 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(83)91693-5