PDGF Induces the Glutathione-Dependent Enzyme PGH 2/PGE 2 Isomerase in NIH3T3 and pEJ Transformed Fibroblasts

Exposure of NIH3T3 and pEJ serum-starved cells to platelet derived growth factor results in a 16 fold increase in the glutathione-dependent enzyme prostaglandin H 2/prostaglandin E 2 isomerase activity (EC 5.3.99.3). The response is rapid as a detectable increase in NIH3T3 cells occurs after only 7...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 198; no. 1; pp. 298 - 303
Main Authors Kelner, M.J., Uglik, S.F.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1994
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Summary:Exposure of NIH3T3 and pEJ serum-starved cells to platelet derived growth factor results in a 16 fold increase in the glutathione-dependent enzyme prostaglandin H 2/prostaglandin E 2 isomerase activity (EC 5.3.99.3). The response is rapid as a detectable increase in NIH3T3 cells occurs after only 7 minutes of exposure to the growth factor. Only a mild increase in another microsomal glutathione-dependent enzyme, microsomal glutathione transferase (EC 2.5.1.18), was detected after a 2 hour exposure to the growth factor.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1994.1042