PDGF Induces the Glutathione-Dependent Enzyme PGH 2/PGE 2 Isomerase in NIH3T3 and pEJ Transformed Fibroblasts
Exposure of NIH3T3 and pEJ serum-starved cells to platelet derived growth factor results in a 16 fold increase in the glutathione-dependent enzyme prostaglandin H 2/prostaglandin E 2 isomerase activity (EC 5.3.99.3). The response is rapid as a detectable increase in NIH3T3 cells occurs after only 7...
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Published in | Biochemical and biophysical research communications Vol. 198; no. 1; pp. 298 - 303 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
1994
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Online Access | Get full text |
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Summary: | Exposure of NIH3T3 and pEJ serum-starved cells to platelet derived growth factor results in a 16 fold increase in the glutathione-dependent enzyme prostaglandin H
2/prostaglandin E
2 isomerase activity (EC 5.3.99.3). The response is rapid as a detectable increase in NIH3T3 cells occurs after only 7 minutes of exposure to the growth factor. Only a mild increase in another microsomal glutathione-dependent enzyme, microsomal glutathione transferase (EC 2.5.1.18), was detected after a 2 hour exposure to the growth factor. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1006/bbrc.1994.1042 |