Bariatric Manipulation of Gastric Arteries: A Systematic Review on the Potential Concept for Obesity Treatment

• Published in: International journal of surgery (London, England)
• Main Authors: Shoar, Saeed, M.D, Saber, Alan A., M.D., MS, FACS, FASMBS, Aladdin, Mohammaed, M.D, Bashah, Moataz M., M.D, AlKuwari, Mohammed J., M.D, Rizwan, Mohamed, M.D, Rosenthal, Raul J., M.D
• Format: Journal Article
• Language: English
• Published: 2016
• Subjects: Surgery; Obesity; Bariatric; Weight Loss; Ghrelin; Gastric Artery Embolization
• ISSN: 1743-9191
• DOI: 10.1016/j.ijsu.2016.10.014

Abstract Background Gastric artery embolization (GAE) has recently received attention as a minimally invasive intervention in bariatric setting. Aims The current systematic review aimed to gather and categorizes the existing data in the literature regarding bariatric gastric artery manipulation. This will highlight this potential concept as a therapeutic modality. Methods A PubMed/Medline search was conducted to identify animal and human studies investigating the effect of gastric artery manipulation on weight, ghrelin, obesity, and tissue adiposity. Results A total of 9 studies comprising 6 animal experiments with 71 animals and 3 human studies with a total of 25 patients were retrieved. Animal subjects underwent chemical embolization while particle embolization was used in human subjects. Five animal studies and 1 human study reported decreased ghrelin concentration. Three animal experiments and 2 human studies showed significant weight change following GAE. There was no report regarding a serious adverse event requiring surgical or interventional management. Conclusion Currently, data supporting the potential role of gastric artery manipulation in decreasing the ghrelin and possible weight loss is scarce.