The anti-cancer and anti-inflammatory actions of 1,25(OH)2 D3

Various epidemiological studies have shown an aetiological link between vitamin D deficiency and cancer incidence. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], has potent anti-cancer activities both in vitro and in vivo . These anti-cancer effects are attained by reg...

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Published inBest Practice & Research: Clinical Endocrinology & Metabolism Vol. 25; no. 4; pp. 593 - 604
Main Authors Vanoirbeek, E, Krishnan, A, Eelen, G, Verlinden, L, Bouillon, R, Feldman, D, Verstuyf, A
Format Journal Article
LanguageEnglish
Published 2011
Subjects
Endocrinology & Metabolism
proliferation
metastasis
inflammation
vitamin D
angiogenesis
apoptosis
cancer
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Summary:Various epidemiological studies have shown an aetiological link between vitamin D deficiency and cancer incidence. The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], has potent anti-cancer activities both in vitro and in vivo . These anti-cancer effects are attained by regulating the transcription of numerous genes that are involved in different pathways to reduce tumorigenesis and are dependent on the cancer cell type. Besides reducing cell growth and inducing apoptosis, 1,25(OH)2 D3 also inhibits angiogenesis and metastasis. Moreover, its potency to inhibit inflammation also contributes to its anti-tumoral activity. Here, we report the different ways in which 1,25(OH)2 D3 interferes with the malignant processes that are activated in cancer cells.
ISSN:1521-690X
1878-1594
DOI:10.1016/j.beem.2011.05.001