Hyperglycemia and free radical imbalance as prognostic factors in acute stroke

We evaluated 395 patients with acute stroke: diabetes mellitus wasdiagnosed in 19.5%, hyperglycemia was observed in 41.8% patientson day 1 and in 48.9% on day 2 after admission. Hyperglycemiaand diabetes were associated with more severe free radical imbalanceand worsened the outcome in stroke patien...

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Published inAnnaly kliničeskoj i èksperimentalʹnoj nevrologii (Online) Vol. 6; no. 4; pp. 26 - 29
Main Authors S. A. Rumyantceva, E. V. Silina, A. S. Orlova, V. A. Orlov, S. B. Bolevich
Format Journal Article
LanguageEnglish
Published Research Center of Neurology 01.02.2017
Subjects
diabetes mellitus
hyperglycemia
oxidative stress
stroke
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Summary:We evaluated 395 patients with acute stroke: diabetes mellitus wasdiagnosed in 19.5%, hyperglycemia was observed in 41.8% patientson day 1 and in 48.9% on day 2 after admission. Hyperglycemiaand diabetes were associated with more severe free radical imbalanceand worsened the outcome in stroke patients, decreasing rehabilitation potential. The increase of malonic dialdehyde(MDA), decrease of antiperoxide plasma activity (APA), hyperglycemiaand high leucocyte count are shown to be prognostic factorsof adverse outcome (death, severe disability), which should betaken into account during antioxidant therapy. The highest mortalityrate, which showed correlation with the size of stroke, wasobserved in patients with hyperglycemia persisting more than 3days after stroke onset, and it was 1.8-fold higher than in patientswith normoglycemia. Indications for target antioxidant therapyare: blood glucose 6.6 mmol/l, leucocyte count 9 700, APClevel 3, and MDA level 4 mol/l
ISSN:2075-5473
2409-2533
DOI:10.17816/psaic256