Atividade de extratos de Arrabidaea chica (Humb. Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas Activity of Arrabidaea chica (Humb. Bonpl.) Verlot extracts obtained by biotechnological processes on fibroblast and human tumor cells

Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anti...

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Published inQuímica nova Vol. 36; no. 3; pp. 431 - 436
Main Authors Denise Taffarello, Michelle Pedroza Jorge, Ilza Maria de Oliveira Sousa, Marta Cristina Teixeira Duarte, Glyn Mara Figueira, Nubia de Cassia Almeida Queiroz, Rodney Alexandre Ferreira Rodrigues, João Ernesto de Carvalho, Ana Lucia Tasca Ruiz Goes, Mary Ann Foglio, José Manuel Riveros, Marcos Nogueira Eberlin, Elaine Cristina Cabral
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 01.01.2013
Subjects
antiproliferative activity
Arrabidaea chica
xylanases
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Summary:Arrabidaea chica (H&B) Verlot is a plant popularly known as Pariri and this species is a known source of anthocyanins, flavonoids and tannins. This report describes an approach involving enzymatic treatment prior to extraction procedures to enhance A chica crude extract anticancer activity. Anticancer activity in human cancer cell lines in vitro using a 48 h SRB cell viability assay was performed to determine growth inhibition and cytotoxic properties. The final extraction yield without enzyme treatment was higher (24.28%) compared to the enzyme-treated material (19.03%), with an enhanced aglycones anthocyanin ratio as determined by HPLC- DAD and LC-MS with direct infusion.
ISSN:0100-4042
1678-7064