Risk Factors of In-hospital Death in COVID-19 Patients: a Meta-analysis

• Published in: Zhongguo quanke yixue Vol. 26; no. 5; pp. 607 - 620
• Main Author: ZHANG Weizong, YUAN Hong, SUN Jindong, YU Huamin, SHI Mingjuan, HU Haiqiang, HE Haiying, YE Li, ZHANG Huihui, BAI Xinghua, SHEN Chaofeng, TU Sijia, WANG Yang, WANG Gang, ZHAO Xiaofeng, YU Tao, LI Cairong, ZHANG Zhi, ZHOU Donglai, CAI Mengyang, NING Le
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.02.2023
• Subjects: covid-19|hospital mortality|risk factors|case-control studies|meta-analysis|root cause analysis
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2022.0211

Background The worldwide COVID-19 pandemic has turned into a global catastrophic public health crisis, and the conclusion about the risk factors of hospital death in COVID-19 patients is not uniform. Objective To explore risk factors of in-hospital death in patients with COVID-19 by a meta-analysis. Methods Case-control studies about risk factors of in-hospital death in COVID-19 patients were searched from databases of the Cochrane Library, ScienceDirect, PubMed, Medline, Wanfang Data, CNKI and CQVIP from inception to October 1, 2021. Literature screening, data extraction and methodological quality assessment were conducted. Meta-analysis was performed using Stata 15.1. Meta-regression was used to explore the potential sources of heterogeneity. Results Eighty studies were included which involving 405 157 cases〔349 923 were survivors (86.37%) , and 55 234 deaths (13.63%) 〕, that were rated as being of high quality by the Newcastle-Ottawa Scale. Meta-analysis showed that being male〔OR=1.49, 95%CI (1.41, 1.57) ,