Association of NSE level with clinical features in pheochromocytoma/paraganglioma

• Published in: Ji chu yi xue yu lin chuang = Jichu yixue yu linchuang = Basic medical sciences and clinics Vol. 44; no. 4; pp. 533 - 538
• Main Author: LI Tianyi, ZHANG Wenqian, CHEN Yinghan, ZHOU Yue, CUI Yunying, WANG Yu, TONG Anli
• Format: Journal Article
• Language: Chinese
• Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College 01.04.2024
• Subjects: neuron specific enolase|pheochromocytoma and paraganglioma|catecholamine|metastasis
• ISSN: 1001-6325
• DOI: 10.16352/j.issn.1001-6325.2024.04.0533

Objective To study the relationship between serum neuron-specific enolase(NSE) and clinical features of pheochromocytoma/paraganglioma(PPGL). Methods Totally 501 PPGL patients diagnosed from January 2019 to December 2022 were divided into normal NSE group(NSE≤16.3 ng/mL) and elevated NSE group(NSE>16.3 ng/mL). The clinical characteristics were compared between the two groups. Results Compared with normal NSE group, patients in the elevated NSE group had larger diameter in primary tumor(5.00 cm vs. 4.60 cm), higher 24-hour urinary norepinephrine(NE) and 24-hour urinary dopamine(DA) levels, and a higher rate of metastasis(31.6% vs. 13.7%)(P＜0.05). NSE level was positively correlated with the primary tumor size(r=0.131, P＜0.05),24-hour urinary NE level(r=0.195, P＜0.05) and 24-hour urinary DA level(r=0.119, P＜0.05). Conclusions The level of NSE is related to tumor size, secretion function and metastasis in PPGL patients.