Risk factors and prognosis of carbapenem-resistant Klebsiella pneumoniae bloodstream infection in ICU patients: a report of 81 cases

• Published in: Waike Lilun yu Shijian Vol. 28; no. 5; pp. 454 - 462
• Main Author: LIU Meng, XU Wen, DAI Yunqi, TAN Ruoming, LIU Jialin, GU Feifei, CHEN Erzhen, WANG Xiaoli, QU Hongping, QIU Yuzhen
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Surgery Concepts & Practice 01.09.2023
• Subjects: carbapenem-resistant klebsiella pneumoniae|bloodstream infection|critically ill patient
• ISSN: 1007-9610
• DOI: 10.16139/j.1007-9610.2023.05.11

Objective Comprehensive mortality risk analyses and therapeutic assessment in real-world practice are beneficial to guide individual treatment in patients with Carbapenem-resistant Klebsiella pneumoniae bloodstream infections (CRKP-BSI). Methods Retrospective analysis of the clinical characteristics of 81 CRKP-BSI patients in our intensive care unit from July 2016 to June 2020, to indentify the risk factors of death and treatment effects of different antibiotic regimens. Results In 81 CRKP-BSI cases, the majority source were from abdominal and respiratory, accounting for 56.79% (46 cases) and 22.22% (18 cases), respectively. The 28-day mortality and hospitalization mortality of CRKP-BSI were 54.32% (44 cases) and 65.43% (53 cases). Multivariate regression analysis suggested that biliary tract disease before admission (P=0.026) and increased SOFA score at the onset of BSI (P=0.006) were independent risk factors for 28-day mortality. There was no statistically significant difference in 28-day mortality between