Quality of life of patients with bronchial asthma combined with obesity, depending on the identification of FTO RS9939609 and RS324011 STAT6 gene polymorphism

• Published in: Miz︠h︡narodnyĭ endokrynolohichnyĭ z︠h︡urnal Vol. 13; no. 6; pp. 424 - 428
• Main Authors: О.B. Melnik, О.I. Fediv
• Format: Journal Article
• Language: English
• Published: Zaslavsky O.Yu 01.09.2017
• Subjects: bronchial asthma; gene polymorphism; obesity; quality of life
• ISSN: 2224-0721; 2307-1427
• DOI: 10.22141/2224-0721.13.6.2017.112884

Background. We purposed to analyse the distribution of polymorphism of the FTO and STAT6 genes and the quality of life in patients with bronchial asthma (BA) combined with obesity. Materials and methods. 117 people aged 18 and 48 years old were surveyed and interviewed. The Ukrainian version of the MOS SF-36 questionnaire was used to determine the role of the correlation between the individual features of the patient with BA and obesity, and the special St. George’s Respiratory Questionnaire — to assess the respiratory function. Results. In patients with asthma associated with obesity, the clinical manifestations of BA are more significant, and the overall quality of life is significantly lower than in patients with isolated asthma. In addition, it was found that the carriers of the A alleles of the FTO gene (T/A, A/A) showed a decrease in the indicators of physical functioning, influence of physical condition on the role functioning, social functioning, impact of emotional state on role functioning, and the carriers of the T alleles of the STAT6 gene (C/T, T/T) showed a more pronounced indicators, such as “symptoms”, “activity”, “influence”, and a decrease in the overall quality of life. Conclusions. The impact of clinical symptoms on the subjective reflection of health in patients with asthma associated with obesity was manifested by changes in the physical and mental component of the questionnaire limiting the social activity of a person, the participation of patients in public life and clearly reflected on the mental state of personality with a predisposition to depression, anxiety, excitement. In addition, the genotypic relationship between the detection of the FTO RS9939609 and the RS324011 STAT6 gene polymorphisms and the quality of life of patients with a combined course of disease was noted.