Inmunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, ?-catenin, and E-cadherin in non tumoral gastric mucous membrane

Different authors have investigated the immunohistochemical expression of some proteins in the adenocarcinoma of the stomach, including cell cycle regulators proteins like p53 and Bcl-2; growth factors (c-erb-B2 and EPO-R); angiogenesis- related markers such as COX-2 and cellular adhesion molecules...

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Published inEuropean journal of histochemistry Vol. 50; no. 4; pp. 285 - 292
Main Authors M Sereno, MA García-Cabezas, J De Castro, P Cejas, E Casado Saenz, C Belda-Iniesta, J Barriuso Feijoo, J Larrauri, M Nistal, M Gonzalez Baron
Format Journal Article
LanguageEnglish
Published PAGEPress Publications 01.06.2009
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Summary:Different authors have investigated the immunohistochemical expression of some proteins in the adenocarcinoma of the stomach, including cell cycle regulators proteins like p53 and Bcl-2; growth factors (c-erb-B2 and EPO-R); angiogenesis- related markers such as COX-2 and cellular adhesion molecules (?-catenin and E-cadherin). While these proteins have been studied in gastric adenocarcinoma, their immunophenotyping in non tumoral gastric mucous membrane remains unexplored. In the present study, we investigated the expression, function and behavior of these proteins in normal gastric mucous membrane to contribute to gain further knowledge on the significance of their loss or overexpression in malignant gastric tumors.
ISSN:1121-760X
2038-8306
DOI:10.4081/998