Research status of IgG4⁃related sialadenitis

IgG4⁃related sialadenitis (IgG4⁃RS) is a type of autoimmune disease that has been recognized in recent years, and the pathogenesis remains unclear. IgG4⁃RS mainly affects the submandibular gland and parotid gland and is characterized by diffuse painless swelling of the bilateral salivary glands and/...

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Published inKou qiang ji bing fang zhi = Journal of prevention and treatment for stomatological diseases Vol. 28; no. 1; pp. 56 - 60
Main Authors SU Weizhe, FAN Yawei, MENG Bing
Format Journal Article
LanguageChinese
Published Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 01.01.2020
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Summary:IgG4⁃related sialadenitis (IgG4⁃RS) is a type of autoimmune disease that has been recognized in recent years, and the pathogenesis remains unclear. IgG4⁃RS mainly affects the submandibular gland and parotid gland and is characterized by diffuse painless swelling of the bilateral salivary glands and/or lacrimal glands, usually lasting more than 3 months. Some patients have accompanying hearing loss or hearing impairment, sinusitis, lymphadenopathy and other symptoms; nearly half of patients have different degrees of salivary gland secretion disorders. Most patients have elevated serum IgG4 levels, but they cannot be used as the only marker for diagnosis. Histopathology remains the“gold standard”for diagnosis. Presently, submandibular gland biopsy is often used for diagnosis. Histopathology showed lym⁃ phoplasmacytic infiltration, occlusive phlebitis, striated fibrosis; immunohistochemistry showed IgG4 + /IgG + plasma cells > 40%, and IgG4 + plasma cell/high⁃power field vision > 10. Glucocorticoids are regarded
ISSN:2096-1456
2096-1456
DOI:10.12016/j.issn.2096⁃1456.2020.01.010