Application Value of Blood Lactate and ROX Index in Humidification High-flow NasalCannula Oxygen Therapy for Elderly Patients with Acute Exacerbationof Chronic Obstructive Pulmonary Disease

• Published in: Guoji laonian yixue zazhi Vol. 45; no. 1; pp. 11 - 17
• Main Authors: Yumei Yang, Ximing Liang, Zhifeng Sun, Chunyun Lai, Jing Zhao
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of International Journal of Geriatrics 01.01.2024
• Subjects: acute exacerbation of chronic obstructive pulmonary disease; blood lactic acid; nasal humidification high-flow oxygen therapy; rox index
• ISSN: 1674-7593
• DOI: 10.3969/j.issn.1674-7593.2024.01.003

Objective To investigate the application value of blood lactic acid(Lac) and ROX index in the treatment of elderly patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) by nasal humidification high-flow oxygen therapy(HFNC). Methods A total of 82 patients with AECOPD who visited the Department of Respiratory and Critical Care Medicine of the Second Medical Center of the PLA General Hospital from March 2020 to March 2023 were selected as the study subjects and treated with HFNC.Patients were divided into effective(n=53) and ineffective(n=29) groups according to the continuous treatment of HFNC for 48 h.The clinical data and serum Lac and ROX indices were compared between the two groups,and the related factors affecting the ineffective treatment of HFNC were analyzed by a mlogistic regression model,the predictive value of blood Lac and ROX indices for the ineffective treatment of HFNC was analyzed by ROC curve. Results The age,acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)