Association among liver biochemical parameters, thyroid gland hormones, and TNF-Alpha in hypothyroid patients compared to euthyroid subjects

Background: Tumor necrosis factor alpha (TNFα) is a 17 kDa, an important soluble pro-inflammatory cytokine, which is involved in some tissue dysfunctions, including thyroid and liver tissue. In spite of its role in thyroid and tissue damage separately, the relationship between this factor and these...

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Bibliographic Details
Published inMedical laboratory journal Vol. 18; no. 5; pp. 31 - 33
Main Authors Noori Noha Alsharifi, Mahin Gholipur, Somayeh Ghorbani, Fatemeh Mohammadzadeh, Safoura Khajeniazi
Format Journal Article
LanguageEnglish
Published Golestan University of Medical Sciences 01.07.2024
Subjects
gamma-glutamyltransferase
hypothyroidism
liver function tests
total protein
tumor necrosis factor-alpha
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Summary:Background: Tumor necrosis factor alpha (TNFα) is a 17 kDa, an important soluble pro-inflammatory cytokine, which is involved in some tissue dysfunctions, including thyroid and liver tissue. In spite of its role in thyroid and tissue damage separately, the relationship between this factor and these two disorders has not been clarified. The aim of the present study was to evaluate liver biochemical parameters and TNFα in hypothyroid patients compared to euthyroid subjects. Methods: To achieve this purpose, samples were transferred into tubes without anticoagulants and then centrifuged immediately to separate the serum. All markers in the serum were measured using commercial kits, including T3, T4, TSH, and TNFα, which were detected using the ELISA method. Liver function tests, including albumin, total bilirubin, and total protein were measured by spectroscopy and the colorimetric method, respectively. In addition, AST, ALT, ALP, and GGT were detected using enzymatic methods. Results: Our results showed that the level of TNFα in hypothyroid patients was significantly higher than that in normal individuals (P = 0.009). TNFα had a significantly positive correlation with TSH and T3 but a negative correlation with T4. Furthermore, AST, ALT, and GGT had a positive correlation with TSH and a negative correlation with albumin, total protein, and total bilirubin. These correlations were insignificant (P < 0.05). Conclusion: According to our data, the positive correlation of TSH with both TNFα and liver function tests may indicate a relationship between thyroid and liver function with each other.
ISSN:2538-4449