Effect of Erigeron breviscapus on collateral circulation in patients with ischemic stroke

• Published in: Xīn yīxué Vol. 53; no. 10; pp. 740 - 745
• Main Author: Zhou Kai, Wu Junhong, Liang Hu, Huang Gelang
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of New Medicine 01.10.2022
• Subjects: collateral circulation|erigeron breviscapus|stroke|ct perfusion imaging|cytokine
• ISSN: 0253-9802
• DOI: 10.3969/j.issn.0253-9802.2022.10.007

Objective To explore the mechanism of Erigeron breviscapus on improving cerebral circulation in patients with ischemic stroke by observing the formation of collateral circulation using CT perfusion imaging （CTP）. Methods Sixty ischemic stroke patients were selected and randomly divided into the treatment （n = 32） and control groups （n = 28）. During the study, there were 3 patients dropped in the treatment group and 2 patients dropped in the control group. Finally, there were 29 cases enrolled in the treatment group and 26 cases enrolled in the control group. All patients in two groups received routine treatment. In the treatment group, intravenous injection of Erigeron breviscapus was given for 2 weeks, and an equivalent amount of normal saline was administered for 2 weeks in the control group. CTP was performed at 1 d after admission （before treatment） and 30 d after admission. Time-point measurement of cerebral blood flow （CBF）, cerebral blood volume （CBV）, time to the peak （TTP） and mean transit time （MMT）