Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates

We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (blaNDM-1)-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. blaNDM-1 was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (blaKPC-2) or aminoglycoside-...

Full description

Saved in:
Bibliographic Details
Published inBrazilian journal of medical and biological research Vol. 48; no. 2; pp. 174 - 177
Main Authors M.G. Quiles, T.T. Rocchetti, L.C. Fehlberg, E.J.U. Kusano, A. Chebabo, R.M.G. Pereira, A.C. Gales, A.C.C. Pignatari
Format Journal Article
LanguageEnglish
Published Associação Brasileira de Divulgação Científica 01.12.2014
Subjects
Carbapenem-resistance
Carbapenemases
Enterobacteriaceae
Methylase
Online AccessGet full text

Cover

More Information
Summary:We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (blaNDM-1)-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. blaNDM-1 was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (blaKPC-2) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of blaNDM-1 in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.
ISSN:1414-431X
DOI:10.1590/1414-431x20144154