Synergistic Moderating Effects of L-Theanine and EGCG for the Prevention of Obesity and Hypercholesterolemia

Based on the high-fat diet of successfully modeled obese and hypercholesterolemic rats, using simvastatin as a positive control，the results of epigallocatechin gallate (EGCG, 83.3 mg·kg−1·d−1) + L-Theanine (16.7 mg·kg−1·d−1), EGCG (100 mg·kg−1·d−1) and L-theanine (100 mg·kg−1·d−1) continuously fed b...

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Published inShipin gongye ke-ji Vol. 43; no. 3; pp. 341 - 350
Main Authors Baogui LIU, Zhiyin CHEN, Yangling ZHANG, Enshuo LIU, Shumin HAN, Wenjun XIAO
Format Journal Article
LanguageChinese
Published The editorial department of Science and Technology of Food Industry 01.02.2022
Subjects
epigallocatechin gallate
hypercholesterolemia
l-theanine
nutritional intervention
obesity
synergistic regulation
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Summary:Based on the high-fat diet of successfully modeled obese and hypercholesterolemic rats, using simvastatin as a positive control，the results of epigallocatechin gallate (EGCG, 83.3 mg·kg−1·d−1) + L-Theanine (16.7 mg·kg−1·d−1), EGCG (100 mg·kg−1·d−1) and L-theanine (100 mg·kg−1·d−1) continuously fed by gavage to high-fat diet SPF-grade SD rats for 56 d were compared to investigate the synergistic moderating effects of L-theanine and EGCG for the prevention of obesity and hypercholesterolemia. The results showed that compared with the normal group, there were significant differences (P<0.05) in body weight and blood lipid level in the high-fat diet group, and the body weight had exceeded 21.2% of the weight of the normal group, and the total serum cholesterol exceeded 79.9% of the normal group, indicating that the obesity and hypercholesterolemia model rats were successfully modeled. Compared with the model group, all intervention groups could effectively inhibit the increase of body weight and blood lipid level
ISSN:1002-0306
DOI:10.13386/j.issn1002-0306.2021050056