Aging and immunology

Immunosenescence is the term to describe the changesassociated with the progressive decrease in immune functionsuch as increasing in the susceptibility to infectious diseases,autoimmunity and cancer of individuals after 60 years of age.This decrease in immune function is associated with changes that...

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Published inEinstein (São Paulo, Brazil) Vol. 6; no. S1; pp. S13 - S20
Main Authors Irina Ewers, Luiz Vicente Rizzo, Jorge Kalil Filho
Format Journal Article
LanguageEnglish
Published Instituto Israelita de Ensino e Pesquisa Albert Einstein 01.03.2008
Subjects
Aging
Apoptosis
Autoimmunity
Cytokines
Immune system/physiopathology
Regulatory
T-Lymphocytes
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Summary:Immunosenescence is the term to describe the changesassociated with the progressive decrease in immune functionsuch as increasing in the susceptibility to infectious diseases,autoimmunity and cancer of individuals after 60 years of age.This decrease in immune function is associated with changes thatcan occur in each step of the triggering of an immune response.The process leading to this decay is multifactorial and complexinvolving diverse changes and reorganization in the regulatorypathways of the immune system, as well as changes in theeffectors functions rather than simply a unidirectional decline inoverall functions.
ISSN:1679-4508