G Protein-coupled receptors as targets for drug design

G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many...

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Bibliographic Details
Published inBiotecnología Aplicada Vol. 26; no. 1; pp. 24 - 33
Main Authors Ania de la Nuez Veulens, Rolando Rodríguez
Format Journal Article
LanguageEnglish
Published Elfos Scientiae
Subjects
7tm
acoplamiento molecular
diseño de fármacos
evaluación virtual
gpcr
modelación molecular
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Summary:G protein-coupled receptors (GPCRs) are the target for more than 50% of the drugs currently on the market, including about 25% of the 100 top-selling drugs. They are considered the most important molecules in the field of drug discovery and design today, mostly due to their role as receptors in many of the basic processes in the body, and because they are present in all tissues. Unfortunately, a structure-based rational design is very difficult for GPCRs; the structures available for modeling purposes are only for family A. Despite this fact, research has continued and progressed, using combined structure-based techniques. This review intends to summarize this work.
ISSN:1027-2852