Biological properties of cord blood hematopoietic stem cells

This article provides an overview of research evolution of umbilical cord blood as a source of hematopoietic stem cells for transplantation. Phased developments of the technology of stem cells detection and selection, their proliferation, differentiation and function assessment using cultivation in...

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Bibliographic Details
Published inOnkogematologii͡a Vol. 6; no. 1; pp. 64 - 75
Main Authors S. A. Rumiantsev, E. Yu. Osipova, S. E. Ipatov, T. V. Shamanskaya, O. A. Mayorova, A. G. Rumyantsev
Format Journal Article
LanguageRussian
Published ABV-press 01.07.2014
Subjects
CD133+ cells
CD34+ cells
cord blood
hematopoietic stem cells
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Summary:This article provides an overview of research evolution of umbilical cord blood as a source of hematopoietic stem cells for transplantation. Phased developments of the technology of stem cells detection and selection, their proliferation, differentiation and function assessment using cultivation in vitro and in vivo in animal model was described. Differences of cord blood stem cells in comparison with those from other sources were described. The role of microenvironment for stem cells self-renewal and differentiation is shown. The possibility of stem cells biological properties modeling on example of using a vector based on HIV type 1 containing Notch genes, to regulate CD133+ and CD34+ cord blood stem cells proliferation is shown.
ISSN:1818-8346