The role of necroptosis in neurosurgical diseases

Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection aft...

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Bibliographic Details
Published inBrazilian journal of medical and biological research Vol. 48; no. 4; pp. 292 - 298
Main Authors T. Liu, Y.H. Bao, Y. Wang, J.Y. Jiang
Format Journal Article
LanguageEnglish
Published Associação Brasileira de Divulgação Científica 01.02.2015
Subjects
Molecular mechanism
Pathogenesis
Programmed cell death
Therapy
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Summary:Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.
ISSN:1414-431X
DOI:10.1590/1414-431x20144310