Investigation of KCNJ11 Gene Variant (rs 5219) in Patients with Diabetes after Liver Transplantation

Background & Objective: The incidence of diabetes in liver transplant recipients is one of the common problems among these patients witha negative effect on the success of the transplant and the patient's life. Post Transplant Diabetes Mellitus (PTDM) has many similarities with type 2 diabe...

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Published inMajallah-i danishgah-i ulum-i pizishki-i Fasa Vol. 4; no. 2; pp. 233 - 242
Main Authors Zahra Parvizi, Negar Azarpira, Leila Kohan, Kurosh Kazemi, Mohammad mahdi Parvizi
Format Journal Article
LanguagePersian
Published Fasa University of Medical Sciences 01.09.2014
Subjects
diabetes after liver transplantation
KCNJ11
liver transplantation
rs5219
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Summary:Background & Objective: The incidence of diabetes in liver transplant recipients is one of the common problems among these patients witha negative effect on the success of the transplant and the patient's life. Post Transplant Diabetes Mellitus (PTDM) has many similarities with type 2 diabetes from pathophysiplogical, clinical, and genetic viewpoints... One of the genotypes involved in PTDMis KCNJ11 (rs 5219) that has role in beta-cell function and has regulator effect on ATP sensitive K channels. The purpose of this study is to review the relation between this polymorphism and diabetes after liver transplantation in an Iranian population.Materials &Methods: This is a case-control study on 120 patients receiving liver transplant, including 60 patients with PTDM and 60 patients without PTDM. White blood cell samples were selected from the cell bank of organ transplantation research centre in Namazi Hospital from patients who had undergone liver transplantation during the years 2008 and2012. Frequency of genotypes in this population was determined by PCR-RFLP method. Toexpress the resultsweused distributionindices andparametric statisticaltests.Results:Statistical analysis shows that there is a significant difference between the genotype and the allele frequencies of the two groups of case and control.. KK genotype (P=0.001; 95%CI (1.60-7.6); OR=1.19 increases the risk of PTDM. Conclusion:Our study shows that there is a relation between the incidence of PTDM and sex, age, prednisolone dosage, KCNJ11 polymorphism, and KK genotype.
ISSN:2228-5105
2228-7329