Ameliorating Effect of Cordyceps militaris on Antibiotic Intestinal Barrier Injury in Mice

• Published in: Shipin gongye ke-ji Vol. 46; no. 15; pp. 383 - 391
• Main Authors: Fengli YU, Jiani WANG, Siqing LIAO, Qi ZHANG, Shenghou WANG, Ze WANG
• Format: Journal Article
• Language: Chinese
• Published: The editorial department of Science and Technology of Food Industry 01.08.2025
• Subjects: antibiotic combination therapy; cordyceps militaris; intestinal barrier injury; intestinal flora
• ISSN: 1002-0306
• DOI: 10.13386/j.issn1002-0306.2024080205

Objective: To investigate the protective effects of Cordyceps militaris on antibiotic-induced intestinal damage in mice, induced by the combined administration of cefuroxime axetil and levofloxacin hydrochloride. Methods: Mice were administered high (5×), medium (3×), and low (1×) doses of cefuroxime axetil and levofloxacin hydrochloride for 14 consecutive days. The general health status of the mice, as well as changes in the morphology of the gastrointestinal tract and intestinal villi, were observed. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), creatinine (CRE), blood urea nitrogen (BUN), lipopolysaccharide (LPS), and diamine oxidase (DAO) were measured to determine the optimal antibiotic combination for inducing intestinal injury. Subsequently, the mice were then randomly divided into three groups: antibiotic injury group (MGT, 5×antibiotics), Cordyceps militaris-treated group (MGY, 5×antibiotics+0.61 g/kg.bw Cordyceps militaris), and blank group (BGT). T