Anticoagulative Effect of Two Species of Brown Algae; Sargassum angustifolium and Cystoseira indica

Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the pres...

Full description

Saved in:
Bibliographic Details
Published inResearch in molecular medicine Vol. 8; no. 3; pp. 115 - 122
Main Authors Narges Obeidi, Mohammad Javad Mousavi, Arghavan Hosseinpouri, Hamideh Malekhayati, Elham Ehsandoost
Format Journal Article
LanguageEnglish
Published Mazandaran University of Medical Sciences and Health Services 01.08.2020
Subjects
anticoagulation
cystoseira indica
fucoidan
sargassum angustifolium
Online AccessGet full text

Cover

More Information
Summary:Background: Fucoidans are a group of sulfated fucose-rich polysaccharides that are isolated from brown marine algae and echinoderms, and recently have been found in seagrasses. Fucoidans, as well as their derivatives, have several beneficial biological effects and therapeutic potentials. In the present study, we aimed to evaluate the anticoagulative effects of two species of brown algae, namely Sargassum angustifolium (S. angustifolium) and Cystoseira indica (C. indica). Methods: Fucoidan C and fucoidan S were extracted by an ethanol/water solvent system from S. angustifolium and C. indicia, respectively.  The anticoagulative effects of fucoidan C and fucoidan S were tested on 10 normal serum samples by evaluating the rate of thrombin time (PT) and prothrombin time (PTT). Results: Both fucoidan C and fucoidan S significantly increased PTT. However, no significant difference was observed in PT. Fucoidan C had a greater effect on PTT prolongation compared with fucoidan S. Conclusion: Both fucoidans extracted from S. angustifolium and C. indicia can be used as anticoagulants in biotechnology and human disorders.
ISSN:2322-1348
2322-133X