Relationship between hepatitis C virus antibody and viral load in HIV-infected individuals: a hospital-based study in Yunnan province

• Published in: Zhongguo gong gong wei sheng = China public health Vol. 40; no. 7; pp. 786 - 789
• Main Authors: Lijuan KANG, Junyi LIU, Yantao ZHU, Mi ZHANG, Nian ZHANG, Qi XIE, Shifang LIU, Jiantao YANG, Xiao LI, Quanying HE, Jiali WANG
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Chinese Journal of Public Health 01.07.2024
• Subjects: hepatitis c viral load; hepatitis c virus antibody; hiv-infected individuals
• ISSN: 1001-0580
• DOI: 10.11847/zgggws1143319

ObjectiveTo understand the correlation between hepatitis C virus (HCV) antibodies and HCV RNA viral load in HIV co-infected individuals and to provide a basis for predicting HCV RNA based on HCV antibody detection. MethodsThe blood samples and relevant data were collected from 979 HIV-infected individuals with HCV antibody detection at the Yunnan Provincial Infectious Disease Hospital from November 2022 to March 2023. HCV antibodies were detected by enzyme-linked immunosorbent assay (ELISA), and HCV RNA was measured by real-time reverse transcription-PCR (qRT-PCR). T-test and chi-squared test were used for data analysis. ResultsAmong all participants, 17.9% (n = 176) were HCV antibody positive, and the positive rates were 17.1% (n = 110) and 19.6% (n = 66) for male and female participants, respectively. The rate of HCV antibody positivity was associated with age (χ2 = 107.662, P < 0.001), with the highest rate of 29.6% in participants aged 41 – 60 years and the lowest rate of 0% in participants younger than 2