Predictive value of T2-FLAIR signal suppression rate for 1p/19q molecular features in lower-grade gliomas

Objective To evaluate the predictive value of T2-fluid attenuated inversion recovery (FLAIR) signal suppression rate for the short arm of chromosome 1 and long arm of chromosome 19 (1p/19q) molecular features in lower-grade gliomas (LGG), and to construct and verify the predictive model based on mag...

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Published inLu jun jun yi da xue xue bao Vol. 46; no. 18; pp. 2121 - 2129
Main Authors WANG Hanwei, ZENG Linlan, ZHAO Mimi
Format Journal Article
LanguageChinese
Published Editorial Office of Journal of Army Medical University 01.09.2024
Subjects
1p/19q
lower-grade gliomas
magnetic resonance imaging
prediction
t2-flair mismatch sign
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Summary:Objective To evaluate the predictive value of T2-fluid attenuated inversion recovery (FLAIR) signal suppression rate for the short arm of chromosome 1 and long arm of chromosome 19 (1p/19q) molecular features in lower-grade gliomas (LGG), and to construct and verify the predictive model based on magnetic resonance imaging (MRI) tumor features and T2-FLAIR signal suppression rate. Methods Clincal and imaging data of the patients with pathologically confirmed supratentorial LGG (WHO grade 2~3) in our medical center from 2017 to 2021 were collected and retrospectively analyzed. According to the results of postoperative molecular pathology, they were divided into 1p/19q-codeleted (1p/19q-Codel) and 1p/19q-noncodeleted (1p/19q-Noncodel) groups. MRI tumor features were blindly assessed by 2 neuroradiologists. Five circular regions of interest were respectively delineated in the tumor area and the normal-appearing white matter in contralateral semioval center using the hot-spot method in order to calculate the T2-FL
ISSN:2097-0927
DOI:10.16016/j.2097-0927.202404029