A Multicenter Randomized Controlled Clinical Trial Study on the Effect of Piwei Peiyuan Decoction Combined with Acupuncture in the Treatment of Chronic Atrophic Gastritis with Intestinal Metaplasia

• Published in: Zhongguo quanke yixue Vol. 27; no. 20; pp. 2466 - 2475
• Main Author: WU Kairui, YE Yu, LI Jiaoyue, PEI Bei, LI Xuejun, CHENG Hongliang
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01.07.2024
• Subjects: chronic atrophic gastritis|intestinal metaplasia|piwei peiyuan decoction|combination of acupuncture and medicine|clinical efficacy|randomized controlled trial
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2023.0823

Background Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) is an independent risk factor for gastric cancer. Long-term inflammation and oxidative stress response stimulate the physical and mental state of patients. Under the modern medical model, proton pump inhibitors and gastric mucosal protective agents are increasingly unable to meet the high drug resistance of patients. It is urgent to seek effective new Chinese medicine treatments and multiple methods to treat CAG and IM. Objective To evaluate the clinical efficacy and safety of modified Piwei Peiyuan Decoction combined with acupuncture in the treatment of CAG with IM. Methods From January 2022 to September 2023, 202 patients with CAG and IM diagnosed by gastroscopy and pathological examination in the Department of Spleen and Stomach, the Center for Preventive Treatment of Disease, the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine and the Third Affiliated Hospital of Beijing University of Traditional Chi