A REPORT OF 4 CASES OF ASSISTED REPRODUCTION AFTER FERTILITY-SPARING SURGERY IN PATIENTS WITH BORDERLINE OVARIAN TUMORS AND LITERATURE REVIEW

Objective To explore the safety of fertility-sparing surgery and the selection of ovulation induction protocols in patients with early-stage borderline ovarian tumors (BOTs). Methods Clinical data were collected from four patients with early-stage BOTs who underwent fertility-sparing surgery and lat...

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Published in精准医学杂志 Vol. 38; no. 5; pp. 396 - 399
Main Author GE Yanxin, LIU Hui, XIANG Yanjie
Format Journal Article
LanguageChinese
Published Editorial Office of Journal of Precision Medicine 01.10.2023
Subjects
ovarian neoplasms|fertility preservation|reproductive techniques, assisted|letrozole|ovulation induction
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Summary:Objective To explore the safety of fertility-sparing surgery and the selection of ovulation induction protocols in patients with early-stage borderline ovarian tumors (BOTs). Methods Clinical data were collected from four patients with early-stage BOTs who underwent fertility-sparing surgery and later sought treatment for infertility with assisted reproduction and successfully delivered in Xinhua Hospital Affiliated to School of Medicine in Shanghai Jiao Tong University from January 2015 to December 2021. The postoperative follow-up and assisted reproduction of the patients were reviewed in combination with the literature. The estrogen levels of patients on HCG day were compared between antagonist protocol, agonist protocol, and letrozole mild stimulation protocol. Results Two of the four patients with early-stage BOTs relapsed after fertility-sparing surgery. The pa-thological type of relapse was BOTs without malignant transformation. No recurrence was observed during follow-up after the se-cond operation. A
ISSN:2096-529X
DOI:10.13362/j.jpmed.202305005