Antiviral Activity of Obtained Extracts from Different Parts of Cupressus sempervirens against Herpes Simplex Virus Type 1

Objective(s)The aim of this study was to search for new antiviral agents from herbal medicines. Ethanol extracts of C. semipervirens, C. semipervirens var. horizontalis and C. semipervirens cv. Cereiformis were used in experiments to test their influence on herpes viruses (HSV-1). Materials and Meth...

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Published inIranian journal of basic medical sciences Vol. 12; no. 43
Main Authors Mehrangiz Khajeh Karamadini, Pezhman Khajeh Karamadini, Masoud Sabouri Ghannad, Zahra Tayarani-Najaran, Seyed Ahmad Emami
Format Journal Article
LanguageEnglish
Published Mashhad University of Medical Sciences 01.09.2009
Subjects
Antiviral activity
Cupressus sempervirens
Cupressusaceae
HSV-1
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Summary:Objective(s)The aim of this study was to search for new antiviral agents from herbal medicines. Ethanol extracts of C. semipervirens, C. semipervirens var. horizontalis and C. semipervirens cv. Cereiformis were used in experiments to test their influence on herpes viruses (HSV-1). Materials and MethodsHeLa cells monolayers were infected with herpes viruses (HSV-1). Antiviral activity of the plant extracts assessed using Hematoxylin & Eosin method and observed under a light microscope. All tests were compared with a positive control, acyclovir.ResultsResults showed that all three plants have antiviral activity against HSV-1 virus. The most active extract was the obtained extract from C. semipervirens. Among the different parts of this medicinal plant tested, the fruit’s extract appeared to possess the strongest anti- HSV activity.ConclusionIn conclusion, of the extracts tested in this survey all showed significant antiviral potency.
ISSN:2008-3866
2008-3874