Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients

• Published in: Journal of the Faculty of Medicine, Baghdad Vol. 51; no. 1
• Main Authors: Eman Sh. AL-Obeidy, Khalida M. Mousawy, Raghad J H AL-Akayshi, Laith A. Kamil
• Format: Journal Article
• Language: English
• Published: College of Medicine University of Baghdad 01.04.2009
• Subjects: AIH, HLA antigen, PCR-SSP
• ISSN: 0041-9419; 2410-8057
• DOI: 10.32007/1170%g42-46

Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis. Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls. Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor. Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out.