急性缺血性卒中患者静脉溶栓后血清微小RNA-874-3p、微小RNA-181a-5p及Wnt/β-catenin信号通路与神经功能预后的关系 Relationship between Serum MicroRNA-874-3p, MicroRNA-181a-5p, Wnt/β-catenin Signaling Pathway and Neurological Function Prognosis in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis

• Published in: Zhongguo cuzhong zazhi Vol. 19; no. 10; pp. 1162 - 1169
• Main Author: CHEN Xubin, XIAO Weiting, YUE Xifeng, HE Nengqing, ZENG Xiaohui
• Format: Journal Article
• Language: Chinese
• Published: Editorial Department of Chinese Journal of Stroke 01.10.2024
• Subjects: acute ischemic stroke; drosophila wingless gene protein/β-linked protein signaling pathway; microribonucleic acid-181a-5p; microribonucleic acid-874-3p; neurological function; prognosis
• ISSN: 1673-5765
• DOI: 10.3969/j.issn.1673-5765.2024.10.009

Abstract: Objective To investigate the relationship between serum microRNA-874-3p (miR-874-3p), microRNA-181a-5p (miR-181a-5p), Wnt/β-catenin signaling pathway and neurological function prognosis in patients with acute ischemic stroke (AIS). Methods AIS patients who received intravenous thrombolytic therapy in Shenzhen Longhua District Central Hospital from March 2021 to December 2022 were prospectively included into the AIS group, and healthy subjects during the same period were selected into the control group. The relative expression levels of serum miR-874-3p, miR-181a-5p and peripheral blood mononuclear cell (PBMC) determination of Wnt/β-catenin were detected and compared between the two groups. Pearson correlation was used to analyze the correlation between the expression of miR-874-3p and miR-181a-5p in serum and the Wnt/β-catenin signaling pathway in AIS patients. All AIS patients were followed up for 3 months after discharge. Patients who completed follow-up were divided into the good neurological fun